2012 iMac 27 - Can you ditch the mechanical drive and run blade SSD only?

iMac Intel 27 EMC 2390 Hard Drive Replacement - iFixit Repair Guide

Offers Mac users the ability to add an additional SSD to their 2012 iMacs. Micro SATA Cables PN# APL-SSD-BLD-7PS Authentic only if sold by Micro SATA

SATA Blade SSD Module - Dual SSD Drive Kit for iMac 27 Inch 2012 Model

Upgrading a 27-inch iMac 5K to 14 terabytes - Replacing the Fusion Drive with both a SSD and an harddisk

I am looking to upgrade my Mac mini 2014 to SSD. What's the difference will be if I just buy external SSD and run Mac OS there and use that as main?

iMac Intel 27 EMC 2639 Blade SSD Replacement - iFixit Repair Guide

iMac Intel 27 EMC 2390 Hard Drive Replacement - iFixit Repair Guide

iMac Intel 27 EMC 2390 Hard Drive Replacement - iFixit Repair Guide

This is my iMac since 2017. It is now considerably slow. Is it worth maxing out my RAM or do I just get a new iMac? : r/mac

Apple Proprietary SSDs: Ultimate Guide to Specs & Upgrades